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Research

Trypanosoma brucei is not only the causative agent of human African sleeping sickness and Nagana, a related animal disease, in sub-Saharan Africa, but has also emerged as valuable model organism to study eukaryote biology. Several processes that were discovered in trypanosomes have later been found to represent general biological events. In addition, trypanosomes often have single copies of organelles, such as the mitochondrion and the Golgi, which makes them interesting organisms to study organelle function and formation, as well as cell differentiation. Trypanosomes can easily be propagated in vitro and are amenable to reverse genetic approaches, including inducible RNAi-mediated silencing of gene expression and (inducible) gene knock-out by homologous recombination.

 

Projects

Phospholipid Biosynthesis in Trypanosoma brucei

Nutrient Transporters in Trypanosoma brucei

Transbilayer Movement of Lipids

Attachment of Trypanosome Proteins to Membranes by Lipids

 

Publications

 

 

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